Thermo Fisher Scientific PHLDA1 Polyclonal Antibody
PHLDA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot에 최적화되어 있으며, 45 kDa 단백질 검출이 가능합니다. 고순도(>95%) 항체로 연구용으로 적합합니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 120–165 of human TDAG51 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553484 |
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 45 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity is a key effector mechanism in immunosurveillance against virus-infected or transformed cells. Two mechanisms are known: the perforin-based process and the FAS-based mechanism involving the transducing molecule FAS (APO-1) and its ligand (FAS-L).
The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein, part of the receptor family that includes CD40, nerve growth factor receptors, and tumor necrosis factor receptors.
FAS antigen is widely expressed on lymphoid cell lines and highly expressed in T cells after TCR crosslinking.
A previously undescribed protein, TDAG51, restores activation-induced apoptosis in cells lacking Fas response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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