Thermo Fisher Scientific Phospho-SHC (Tyr239, Tyr240) Polyclonal Antibody
인간, 생쥐, 랫트에 반응하는 Rabbit Polyclonal 항체로 SHC 단백질의 Tyr239/240 인산화 부위를 인식. Western blot과 Immunocytochemistry에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태. -20°C 보관, 연구용 전용.
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-SHC (Tyr239, Tyr240) Polyclonal Antibody
Applications and Tested Dilutions
- Western Blot (WB): 1:1,000
- Immunocytochemistry (ICC/IF): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr239/240 of human Shc |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979346 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex. Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays. In normal tissues, Skp2 is expressed in tonsil and placenta. In tumor tissues, Skp2 is expressed widely, in some colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers. Research suggests that Skp2 plays a role in oncogenesis, particularly in the pathogenesis of lymphomas and breast cancers.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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