Thermo Fisher Scientific GCK Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:1,000
Publications: [References not provided]

Product Specifications

Product Specific Information

• It is not recommended to aliquot this antibody.
• This antibody is not cross-reactive with HPK or other members of the GCK family.

Target Information

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway.
Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver.
The protein localizes to the outer membrane of mitochondria.
Unlike other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant.
Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2), and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(PA5-17711_GCK_P35557-1_Rabbit.svg 및 PA5-17711_GCK_P35557-1_Rabbit_PDP.jpeg)