Thermo Fisher Scientific p38 MAPK alpha Polyclonal Antibody

Thermo Fisher Scientific p38 MAPK alpha Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• It is not recommended to aliquot this antibody.
• This antibody is not cross-reactive with other p38 MAPK isoforms such as β, γ, or δ.

Target Information

MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs.
The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals.
p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motif.
There are four isoforms of p38 MAPK, differing in tissue expression and affinity for upstream activators and downstream effectors.
When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation.
Activated MAPK kinase-3/6 phosphorylates each residue of Thr180 and Tyr182 in p38 MAPK.
Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2, and other transcription factors through phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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