Thermo Fisher Scientific DOCK3 Polyclonal Antibody
Human DOCK3 단백질을 인식하는 Sheep 유래 Polyclonal Antibody로, IHC(P) 등 다양한 연구용 응용에 적합. 높은 특이성과 낮은 교차 반응성을 보이며, E. coli 유래 재조합 항원으로 제작됨. Lyophilized 형태로 안정적 보관 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5–15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant human DOCK3 (Gly418–Thr656) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606777 |
Product Specific Information
- In direct ELISAs, less than 3% cross-reactivity with recombinant human DOCK1, DOCK2, and DOCK5 is observed.
- Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
Dedicator of cytokinesis 3 (DOCK3), also known as MOCA and PBP, is a ~180 kDa protein involved in signal transduction.
It acts as a guanine nucleotide exchange factor (GEF) that activates small GTPases by exchanging bound GDP for free GTP.
DOCK3 is associated with Alzheimer’s disease tangles and regulates amyloid precursor protein and beta-amyloid accumulation.
Overexpression in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling.
It binds and inactivates glycogen synthase kinase-3β (GSK-3β), promoting axon branching and microtubule assembly.
By stimulating actin polymerization and microtubule assembly, DOCK3 plays an essential role in BDNF signaling in the CNS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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