Thermo Fisher Scientific ITCH/AIP4 Polyclonal Antibody, Biotin
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA, IP에 사용 가능. Biotin 결합형으로 높은 특이성과 민감도 제공. Affinity chromatography로 정제되어 안정적인 신호 검출 가능.
- 카탈로그번호
- ITCH-BIOTIN
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 250–300 on human ITCH protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1 and belongs to the NEDD4-like protein family. These proteins are E3 ubiquitin-ligase molecules that regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes.
This encoded protein contains four tandem WW domains and a HECT domain, acts as a transcriptional corepressor of p45/NFE2, and may regulate immune responses via Notch-mediated signaling. It shows high similarity to the mouse Itch protein, which is implicated in the regulation and differentiation of erythroid and lymphoid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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