Thermo Fisher Scientific ITCH/AIP4 Polyclonal Antibody
ITCH/AIP4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA, IP 등 다양한 응용에 적합. 고순도 친화 크로마토그래피 정제, 안정적인 액상 형태로 제공. 인체, 생쥐, 랫트 반응성.
- 카탈로그번호
- ITCH-101AP
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific ITCH/AIP4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 250–300 on human ITCH protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1 and is a member of the NEDD4-like protein family. These proteins act as E3 ubiquitin-ligases regulating trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT domain, functioning as a transcriptional corepressor of p45/NFE2 and possibly participating in immune response regulation through Notch-mediated signaling. It is highly similar to the mouse Itch protein, involved in erythroid and lymphoid cell regulation and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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