Thermo Fisher Scientific VDAC Polyclonal Antibody
Rabbit polyclonal antibody targeting human VDAC1 (aa 188–231). Validated for WB, IHC(P), and ICC/IF. High specificity via antigen affinity purification. Supplied as liquid form (1 mg/mL) in PBS buffer with glycerol and BSA. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human VDAC1 aa 188–231 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932463 |
Target Information
Voltage-dependent anion channel (VDAC) proteins are abundant pore-forming proteins located in the eukaryotic mitochondrial outer membrane and also expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins play an essential role in cellular metabolism and in the early stages of apoptosis. VDAC forms a major pathway for metabolite exchange between the cytosol and mitochondria (e.g., ADP/ATP, succinate, citrate). VDAC1 in the plasma membrane may regulate apoptosis through its redox activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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