Thermo Fisher Scientific Lamin-A Polyclonal Antibody
Lamin A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용 가능. 인간 Lamin A의 550-600번 잔기 영역을 면역원으로 사용. 4°C 보관, 1년 안정성 보장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 550 and 600 of human Lamin A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Rat and Pig
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic side of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type and B-type lamins.
A-type lamins include lamin A, lamin C, and lamin Adel 10, arising from the same gene by alternative splicing.
B-type lamins include lamin B1 and lamin B2, encoded by distinct genes.
Mutations in A-type lamins are associated with several rare dominant genetic disorders such as Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease, and Dunnigan-type familial partial lipodystrophy.
Expression of A-type lamins coincides with cell differentiation and their interaction with chromatin suggests a role in differential gene expression regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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