Thermo Fisher Scientific Synaptotagmin 1 Polyclonal Antibody
Synaptotagmin 1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제, 고농도 액상 형태. 신경전달 관련 연구에 유용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:10,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 69–313 of Human Synaptotagmin 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547396 |
Product Specific Information
- Recommended positive controls: mouse brain, rat brain
- Predicted reactivity: Mouse (100%), Rat (100%), Chicken (96%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly before opening the vial.
Target Information
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein widely expressed throughout the CNS and acts as the Ca²⁺ sensor in exocytosis and neurotransmitter release. It binds SNAP25 in a Ca²⁺-dependent manner, essential for membrane triggering. Specific residues in the C2B domain regulate endocytic rate and vesicle size. Synaptotagmin 1 interacts with acidic phospholipids and proteins such as neurexins, syntaxin, and AP2, both Ca²⁺-dependent and independent. Dysfunction is associated with food-borne and infant botulism.
⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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(이미지 파일명: PA5-29922_Synaptotagmin_1_P21579-1_Rabbit.svg, PA5-29922_Synaptotagmin_1_P21579-1_Rabbit_PDP.jpeg)
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