Thermo Fisher Scientific CUGBP1 Polyclonal Antibody
CUGBP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며 Human에 반응. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 75–275 of Human CUGBP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.24 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547397 |
Product Specific Information
- Recommended positive control: A549
- Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (80%), Xenopus laevis (82%), Chicken (95%), Chimpanzee (100%), Bovine (95%)
- Store as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Myotonic dystrophy (MD) is an autosomal dominant neuromuscular disease associated with a (CTG)n repeat expansion in the 3’-untranslated region of the myotonin protein kinase (Mt-PK) gene. A (CUG)n oligonucleotides triplet repeat pre-mRNA/mRNA binding protein may play an important role in DM pathogenesis.
HeLa cell protein CUG-BP1 binds specifically to (CUG)8 oligonucleotides in vitro and represents the major (CUG)8 binding activity in normal cells. CUG-BP1 has been identified as isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50.
The CUG-BP/hNab50 protein is localized predominantly in the nucleus and associates with polyadenylated RNAs in vivo. In vitro RNA-binding and photocrosslinking studies demonstrate that CUG-BP/hNab50 binds to RNAs containing the Mt-PK 3’-UTR. Triplet repeat expansion leads to sequestration of this hnRNP on mutant Mt-PK transcripts.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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