Thermo Fisher Scientific PON1 Polyclonal Antibody
Thermo Fisher Scientific의 PON1 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 Rabbit IgG 항체입니다. Western blot 및 ELISA에 적합하며, 재조합 단백질(aa 9-109)을 면역원으로 사용했습니다. 고순도 친화 크로마토그래피 정제 및 -20°C 보관 조건을 권장합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 9–109 of human PON1 (NP_000437.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.95 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2913769 |
Product Specific Information
Positive test controls include: HepG2, NCI-H460, HT-1080, THP-1, Mouse kidney, Rat kidney.
The target is usually found in the following locations: Secreted, extracellular space.
Immunogen sequence:
LLGMGLALFR NHQSSYQTRL NALREVQPVE LPNCNLVKGI ETGSEDLEIL PNGLAFISSG LKYPGIKSFN PNSPGKILLM DLNEEDPTVL ELGITGSKFD V
Target Information
The paraoxonase (PON) gene family in humans has three members: PON1, PON2, and PON3, aligned next to each other on chromosome 7q21.3–22.1.
PON1 is synthesized primarily in the liver and secreted into plasma, where it associates with high-density lipoproteins (HDL).
It hydrolyzes active metabolites of several organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon) and nerve agents such as sarin, soman, and VX.
PON1 polymorphism may contribute to neurodegeneration and is considered an independent risk factor for Parkinson’s disease.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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