Thermo Fisher Scientific THOC5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 150-370 of human THOC5 (NP_0036694) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:THOC5,uniProtId:Q13769-1,ncbiNodeId:9606,antigenRange:150-370,antigenLength:683,antigenImageFileName:PA5-88191_THOC5_Q13769-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88191_THOC5_Q13769-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.03 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804731

Product Specific Information

Immunogen sequence: FKSKHEEIDL VSLEEFYKEA PPDISKAEVT MGDPHQQTLA RLDWELEQRK RLAEKYRECL SNKEKILKEI EVKKEYLSSL QPRLNSIMQA SLPVQEYLFM PFDQAHKQYE TARHLPPPLY VLFVQATAYG QACDKTLSVA IEGSVDEAKA LFKPPEDSQD DESDSDAEEE QTTKRRRPTL GVQLDDKRKE MLKRHPLSVM LDLKCKDDSV LHLTFYYLMN L; Positive Samples: HT-29, Mouse testis, Rat testis; Cellular Location: Cytoplasm, Nucleus, Nucleus speckle

Target Information

Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and THOC4. UAP56 functions as a bridge between THOC4 and the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. May be involved in the differentiation of granulocytes and adipocytes.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.