Thermo Fisher Scientific P-Selectin Polyclonal Antibody
P-selectin을 인식하는 Rabbit Polyclonal Antibody로 Western blot에 적합합니다. Rat, Human, Mouse에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 고순도(>95%)를 유지합니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in Human SELP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803614 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in the regulation of cell rolling. It is stored in the Weibel-Palade bodies of endothelial cells and in α-granules of platelets. Upon stimulation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or adenosine diphosphate, P-selectin is rapidly translocated to the cell surface.
P-selectin mediates interactions between activated endothelial cells or platelets and leukocytes, functioning as a calcium-dependent receptor binding to sialylated Lewis blood group carbohydrate antigens on neutrophils and monocytes. It plays a key role in leukocyte-endothelial adhesion, inflammation, atherogenesis, thrombosis, and tissue injury. Clinically, P-selectin is used to differentiate heparin-induced thrombocytopenia with and without thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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