Thermo Fisher Scientific IGF1 Polyclonal Antibody
IGF1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 다클론 항체입니다. Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용에 사용 가능합니다. 인간에 반응하며 다른 종에도 예측 반응성을 보입니다. 연구용으로만 사용됩니다.
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- PA519382
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | View 1 publication |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | – |
| Flow Cytometry (Flow) | 10 µg/mL | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (RSVRAQRHTD) corresponding to internal amino acids of IGF1 (aa 119–129) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10989408 |
Product Specific Information
- Predicted to react with bovine, canine, mouse, porcine, rabbit, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
IGF1 (Insulin-like growth factor-1) is structurally and functionally related to insulin but exhibits much higher growth-promoting activity. It induces various cellular responses including proliferation, differentiation, migration, and survival. IGF1 acts as a polypeptide growth factor stimulating the proliferation of cell types in muscle, bone, and cartilage tissues. It enhances glucose transport and metabolism in osteoblastic cells at lower concentrations than insulin.
In circulation, IGFs are primarily bound to IGF-binding proteins (IGFBPs), which extend their half-life and regulate tissue targeting. IGF1 is a potent activator of the AKT signaling pathway, promoting cell proliferation and inhibiting apoptosis. Mature human IGF1 shares 100% homology with bovine and porcine proteins. Low IGF1 levels have been associated with Alzheimer’s disease. Defects in the IGF1 gene cause insulin-like growth factor 1 deficiency, and multiple transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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