Thermo Fisher Scientific Human TXK, GST Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution: Assay-dependent
Publications: Refer to Thermo Fisher Scientific resources.

Product Specifications

Product Specific Information

For maximum recovery, please spin prior to use.
Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
For larger sizes, reduce freeze/thaw cycles by preparing aliquots (not below 20 µL).
Never store kinase diluted.
When properly stored at -80°C, product is guaranteed for 6 months from date of purchase.

Protein Form: Recombinant, Catalytic Domain

Target Information

TXK, along with its relatives BMS, ITK, and BTK, signals downstream of antigen and other receptors.
All family members contain SH3 and SH2 domains, and most (except Txk and Dsrc28C) also have pleckstrin homology (PH) and Tec homology (TH) domains in their amino termini.
Four alternatively spliced forms of Tec are expressed in hematopoietic cells and hepatocytes.
The Emt gene product associates with CD28 and is activated after CD28 ligation.
Btk is essential for proper B cell development; mutations cause X-linked agammaglobulinemia (Bruton’s disease).
Bmx shares high homology with Btk and is highly expressed in the heart.
Txk expression is T cell-specific, while Dsrc28C expression in Drosophila is developmentally regulated.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.