Thermo Fisher Scientific Human EIF2AK1 (HRI), GST Tag Recombinant Protein

Thermo Fisher Scientific Human EIF2AK1 (HRI), GST Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution

• Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use original packaging until exhausted.
• For larger sizes, reduce freeze/thaw cycles by preparing aliquots (not below 20 µL).
• Never store kinase diluted.
• Proper storage at -80°C ensures stability for 6 months from date of purchase.
• Protein Form: Full Length

Target Information

EIF2AK1 (HRI) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to decreased protein synthesis. EIF2AK1 signaling is initiated by low levels of heme. The HRI gene is localized to 7p22, where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands, with kinase activity induced by low heme and inhibited by heme presence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.