Thermo Fisher Scientific GSTM2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Peptide sequence: TQSNAILRYI ARKHNLCGES EKEQIREDIL ENQFMDSRMQ LAKLCYDPDF
• Sequence homology: Human: 100%; Zebrafish: 79%

Target Information

At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
GSTM2 is a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress, by conjugation with glutathione.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual’s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.