Thermo Fisher Scientific CYP4F3 Polyclonal Antibody
Thermo Fisher Scientific의 CYP4F3 Polyclonal Antibody는 인간 CYP4F3 단백질을 인식하는 토끼 유래 IgG 항체로, Western blot과 IHC(P)에 적합합니다. 합성 펩타이드 면역원으로 제작되었으며, 약물 대사 및 염증 조절 연구에 유용합니다.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human CYP4F3 (aa 35–84) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2608047 |
Product Specific Information
Peptide sequence:
LAWTYTFYDN CCRLRCFPQP PKRNWFLGHL GLIHSSEEGL LYTQSLACTF
Sequence homology:
- Dog: 86%
- Human: 100%
- Mouse: 85%
- Rat: 85%
Target Information
Cytochrome P450 superfamily proteins are monooxygenases involved in drug metabolism and the synthesis of cholesterol, steroids, and lipids.
CYP4F3, a 60 kDa protein, is a member of this family and contains a conserved heme-binding domain near the C-terminus. It catalyzes the ω-hydroxylation of LTB4 and is localized in the endoplasmic reticulum, playing a key role in LTB4 inactivation and inflammation control.
CYP4F3 exists in two isoforms:
- CYP4F3A (neutrophil isoform): Expressed in neutrophils and myeloid cells, catalyzes microsomal ω-hydroxylation of LTB4, and interacts with CD11b and myeloperoxidase to regulate myeloid cell development.
- CYP4F3B (liver isoform): Converts arachidonic acid to 20-HETE, which activates PKC and is implicated in cell proliferation, vascular tone, and natriuresis.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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