Thermo Fisher Scientific PON3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Immunohistochemistry (IHC)

• Tested Dilution: 5 µg/mL

Product Specifications

Product Specific Information

Peptide sequence:
PMKLLNYNPE DPPGSEVLRI QNVLSEKPRV STVYANNGSV LQGTSVASVY

Sequence homology:
Cow: 85%
Dog: 100%
Horse: 93%
Human: 100%
Mouse: 100%
Pig: 93%
Rabbit: 100%
Rat: 100%

Target Information

Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase associated with apoA-I in HDL. PON1 prevents LDL oxidation and formation of atherogenic oxidized-LDL. Polymorphisms of the human PON1 gene correlate with coronary artery disease, suggesting a genetic link. PON1 activity is lower in individuals prone to atherosclerosis (e.g., diabetes, familial hypercholesterolemia, renal disease).
PON2 is an intracellular protein that protects cells against oxidative damage. PON3 is similar to PON1 in function but differs in substrate specificity. Both PON1 and PON3 are implicated in reducing the risk of coronary artery disease and atherosclerosis. Human PON3 shares three conserved cysteine residues with PON1, important for in vivo activity.
PON1-based catalytic scavengers may offer a safe and effective approach to organophosphate detoxification.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.