Thermo Fisher Scientific VEGF Receptor 1 Polyclonal Antibody
VEGF Receptor 1(Flt-1)을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC 등 다양한 어플리케이션에 사용 가능하며, Protein A로 정제된 1 mg/mL 액상 시약입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 5–10 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | – | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | – |
| Immunocytochemistry (ICC/IF) | – | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminus of the Flt-1 precursor of human origin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11007508 |
Product Specific Information
PA5-16493 targets Flt-1 in Western blot applications and shows reactivity with mouse, rat, and human samples.
The immunogen is a synthetic peptide from the C-terminus of the human Flt-1 precursor.
Target Information
FLT1 (VEGFR1) is a receptor tyrosine kinase critical for angiogenesis. It is involved in both physiological and pathological processes such as tumor progression, diabetic retinopathy, rheumatoid arthritis, and wound healing.
FLT1 may act as a negative regulator of embryonic angiogenesis by inhibiting excessive endothelial cell proliferation. In adults, it can promote endothelial cell proliferation, survival, and angiogenesis, depending on the cell type.
It binds VEGFA with high affinity but has relatively low kinase activity, potentially functioning as a negative regulator by sequestering VEGFA and preventing binding to KDR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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