Thermo Fisher Scientific c-Met Recombinant Rabbit Monoclonal Antibody (SJ19-05)
Thermo Fisher Scientific의 c-Met Recombinant Rabbit Monoclonal Antibody (SJ19-05)는 인간 c-Met 단백질을 표적하는 고특이성 항체입니다. Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용에 적합하며, 고순도 Protein A 정제 및 안정적 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SJ19-05 |
| Immunogen | Synthetic peptide within C-terminal human Met |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898867 |
Target Information
MET (c-Met) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. These interactions activate signaling cascades including RAS-ERK, PI3K-AKT, and PLCγ-PKC pathways.
MET plays a crucial role in embryonic development such as gastrulation, muscle and neuron development, angiogenesis, and kidney formation. In adults, it contributes to wound healing, organ regeneration, and tissue remodeling.
Dysregulation of MET has been associated with cancers including gastric, renal, and breast, making it a key target for cancer therapeutics and diagnostic testing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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