Thermo Fisher Scientific PTPRG Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide derived from residues 1000 - 1100 of Human PTP gamma. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PTPRG,uniProtId:P23470-1,ncbiNodeId:9606,antigenRange:1000-1100,antigenLength:1445,antigenImageFileName:PA5-19458_PTPRG_P23470-1_Rabbit.svg,antigenImageFileNamePDP:PA5-19458_PTPRG_P23470-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10981249

Product Specific Information

PA5-19458 targets PTP gamma in WB applications and shows reactivity with Human samples.

The PA5-19458 immunogen is synthetic peptide derived from residues 1000 - 1100 of Human PTP gamma.

PA5-19458 detects PTP gamma which has a predicted molecular weight of approximately 50-70 kDa.

Target Information

RPTP gamma, also known as Receptor-type tyrosine-protein phosphatase gamma, R-PTP-gamma or PTPRG is a protein tyrosine phosphatase (PTP) is a candidate tumor suppressor gene since it is located on human chromosome 3p14.2-p21, a region frequently deleted in certain types of renal and lung carcinomas. In situ hybridization analysis reveals that RPTP gamma mRNA is expressed in specific regions of the brain and that the localization of RPTP gamma changes during brain development. RPTP gamma is composed of a putative extracellular domain, a single transmembrane domain, and a cytoplasmic portion with two tandem catalytic tyrosine phosphatase domains. The extracellular domain contains a stretch of 266 amino acids with striking homology to the zinc-containing enzyme carbonic anhydrase (CAH), indicating that RPTP gamma and RPTP beta (HPTP zeta) represent a subfamily of receptor tyrosine phosphatases. RPTP gamma may have a function other than catalysis of hydration of metabolic CO2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.