Thermo Fisher Scientific HKDC1 Polyclonal Antibody
Thermo Fisher Scientific HKDC1 Polyclonal Antibody는 인간 HKDC1 단백질을 인식하는 토끼 IgG 폴리클로날 항체입니다. ICC/IF 실험에 사용되며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 4°C 또는 -20°C에서 안정적으로 보관 가능합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human HKDC1. Recombinant protein control fragment (Product #RP-107319) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663426 |
Product Specific Information
Immunogen sequence:
VQAQRKQIDRV LALFQLTREQ LVDVQAKMRA ELEYGLKKKS HGLATVRMLP TYVCGLPDGT EK
Highest antigen sequence identity to the following orthologs:
- Mouse: 84%
- Rat: 46%
Target Information
HKDC1 (ErbB-1; HER1 in humans) is a cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It belongs to the ErbB receptor family, which includes HKDC1 (ErbB-1), HER2/c-neu (ErbB-2), Her3 (ErbB-3), and Her4 (ErbB-4).
HKDC1 is activated by binding specific ligands such as epidermal growth factor and transforming growth factor alpha (TGFα). These signaling molecules regulate cell proliferation, differentiation, motility, survival, and tissue development.
Mutations or overexpression of HKDC1 are associated with cancers including lung cancer and glioblastoma multiforme, where the HKDC1vIII mutation is often observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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