Thermo Fisher Scientific Akirin2 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human Akirin2 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:AKIRIN2,uniProtId:Q53H80-1,ncbiNodeId:9606,antigenRange:56-136,antigenLength:203,antigenImageFileName:PA5-66674_AKIRIN2_Q53H80-1_Rabbit.svg,antigenImageFileNamePDP:PA5-66674_AKIRIN2_Q53H80-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2663482

Product Specific Information

Immunogen sequence: ASPQKYLRMEP SPFGDVSSRL TTEQILYNIK QEYKRMQKRR HLETSFQQTD PCCTSDAQPH AFLLSGPASP GTSSAASSPL

Highest antigen sequence identity to the following orthologs - mouse 93%, rat 93%.

Target Information

The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappa-B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappa-B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-a and IL-1-b signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.