Thermo Fisher Scientific Akirin2 Polyclonal Antibody
Rabbit polyclonal antibody against human Akirin2 protein. Recognizes recombinant Akirin2 with high species conservation (mouse/rat 93%). Supplied as liquid form, unconjugated, 0.2 mg/mL concentration. Suitable for research use only, not for diagnostic ...
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Thermo Fisher Scientific Akirin2 Polyclonal Antibody
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Akirin2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663482 |
Product Specific Information
Immunogen sequence:
ASPQKYLRMEP SPFGDVSSRL TTEQILYNIK QEYKRMQKRR HLETSFQQTD PCCTSDAQPH AFLLSGPASP GTSSAASSPL
Highest antigen sequence identity to the following orthologs:
- Mouse: 93%
- Rat: 93%
Target Information
Akirin1 and Akirin2 are highly conserved, nuclear-localized proteins that regulate transcription of NF-kappa-B-dependent genes. They are essential for defense against Gram-negative bacteria through immune deficiency and NF-kappa-B pathways.
Akirin1 is dispensable in mice, while Akirin2 is required for development and functions downstream of toll-like receptor (TLR), TNF-α, and IL-1β signaling, contributing to IL-6 production.
In Drosophila, Akirin2 is functionally similar to the single Akirin gene, with mutants showing mid-to-early embryonic lethality.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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