Thermo Fisher Scientific Complement C3 beta chain Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal 항체로 Complement C3 beta chain을 인식. Western blot, IHC(frozen), ELISA에 적합. Protein A로 정제된 1 mg/mL 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Complement C3 beta chain Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Complement C3 beta chain, amino acids 581–667 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Inactive complement component 3b (iC3b) is a 42 kDa neoantigen present in blood serum. Cleavage of C3b into iC3b by the protease factor I, in the presence of cofactors, alters its structure and binding properties, preventing interaction with complement factor B and properdin. This regulation halts further progression of the complement cascade.
iC3b is thought to play a role in immune tolerance by binding complement receptor type 3 on antigen-presenting cells, stimulating production of transforming growth factor beta2 and interleukin-10. It also interacts with B-cells via the CD21 receptor, linking innate and adaptive immunity. Additionally, iC3b acts as an opsonin recognized by complement receptor 3 on leukocytes or CRIg on Kupffer cells, promoting phagocytosis of tagged cells.
Elevated iC3b levels are associated with autoimmune diseases such as Systemic Lupus Erythematosus and Rheumatoid Arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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