Thermo Fisher Scientific OLFM1 Polyclonal Antibody
OLFM1 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(Paraffin)에 적합합니다. 인간, 마우스, 랫드 등 다양한 종에 반응하며, PBS/glycerol buffer에 보관됩니다. 신경계 발달 관련 연구에 유용한 연구용 항체입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human OLFM1 (Accession Q99784), corresponding to amino acid residues F312–S362 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2851719 |
Product Specific Information
Antibody detects endogenous levels of total OLFM1.
Target Information
The Olfactomedin family comprises a diverse group of secreted glycoproteins, including OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin, and myocilin. These proteins are implicated in the development of the nervous system.
OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse at E8–10, and later in brain tissue and in the zone of polarizing activity in the limb.
Overexpression of OLFM1 causes an excess of neural crest emigrations and prolonged neural crest production. OLFM2 participates in the regulation of the development of the anterior nervous system.
An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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