Thermo Fisher Scientific MTM1 Polyclonal Antibody
MTM1 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, Human, Mouse, Rat에 반응합니다. Western blot 및 IHC(Paraffin) 실험에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. PBS 기반 용액 형태로 -20°C에서 보관합니다.
- 카탈로그번호
- PA5102308
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: [참고 문헌 링크 없음]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: [참고 문헌 링크 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MTM1 (Accession Q13496), corresponding to amino acid residues R570–F603 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2851717 |
Product Specific Information
Antibody detects endogenous levels of total MTM1.
Target Information
Human MTM1 is a 603 amino-acid protein mutated in myotubular myopathy. The related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-Tooth neuropathy.
Myotubularin functions as a lipid phosphatase acting on phosphatidylinositol 3-monophosphate, regulating the PI 3-kinase pathway and membrane trafficking.
Wildtype myotubularin can dephosphorylate PI 3-P and PI 4-P in vitro, thereby decreasing PI 3-P levels through down-regulation of PI 3-K activity and facilitating PI 3-P degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 정보: PA5-102308_MTM1_Q13496-1_Rabbit.svg, PA5-102308_MTM1_Q13496-1_Rabbit_PDP.jpeg)
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