Thermo Fisher Scientific OPRK1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:3000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated Cys-RVRNTVQDPAYLRDIDGMNKPV if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:OPRK1,uniProtId:P41145-1,ncbiNodeId:9606,antigenRange:359-380,antigenLength:380,antigenImageFileName:PA3-028_OPRK1_P41145-1_Rabbit.svg,antigenImageFileNamePDP:PA3-028_OPRK1_P41145-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

0.05% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2540489

Product Specific Information

IHC (P) analysis shows positive staining of KOR in human brain.

WB analysis shows KOR in glycoprotein-enriched fractions from mock transfected or KOR overexpressing 293 cells.

While KOR has a theoretical MW of ~ 43kD, the observed band in a WB runs at ~60kD due to enrichment of the glycosylated receptor.

Target Information

This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.