Thermo Fisher Scientific IDO1 Monoclonal Antibody (OTI1A3), TrueMAB

Thermo Fisher Scientific IDO1 Monoclonal Antibody (OTI1A3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of regulatory molecules such as tryptophan, serotonin, and melatonin. This process produces biologically active metabolites known as kynurenines.
IDO1 is expressed in various human tissues, macrophages, and dendritic cells. During inflammation, interferons (IFNs) induce IDO1 expression, contributing to antimicrobial defense by depleting tryptophan, thereby inhibiting the growth of viruses, bacteria, and parasites.
Additionally, IDO1 plays a crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and tumorigenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.