Thermo Fisher Scientific DKC1 Polyclonal Antibody
DKC1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunocytochemistry에 적합. Human, Mouse, Rat 시료에 반응하며, Affinity chromatography로 정제됨. PBS buffer(50% glycerol) 보관, -20°C에서 안정적 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DKC1 (Accession O60832), corresponding to amino acid residues R183–L233 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850512 |
Product Specific Information
Antibody detects endogenous levels of total DKC1.
Target Information
This gene is a member of the H/ACA snoRNPs gene family. snoRNPs are involved in rRNA processing and modification and are classified into C/D and H/ACA families. The H/ACA snoRNPs include NOLA1, NOLA2, and NOLA3 proteins. The DKC1 protein and NOLA proteins localize to the dense fibrillar components of nucleoli and coiled bodies in the nucleus. Depletion of any of these proteins impairs 18S rRNA production and rRNA pseudouridylation. These proteins are also components of the telomerase complex. Mutations in DKC1 cause X-linked dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome, a more severe form of the disease. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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