Thermo Fisher Scientific MID1 Polyclonal Antibody
MID1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC(P), ICC/IF에 사용 가능. 인간, 마우스, 랫트에 반응하며, 친화 크로마토그래피로 정제된 액상 형태. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MID1 (Accession O15344), corresponding to amino acid residues I83–T133 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850504 |
Product Specific Information
Antibody detects endogenous levels of total TRI18.
Target Information
Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1.
Midline-1 belongs to the TRIM/RBCC family and contains:
- Two B box-type zinc fingers
- One B30.2/SPRY domain
- One COS domain
- One fibronectin type-III domain
- One RING-type zinc finger
Midline-1 is believed to have E3 ubiquitin ligase activity, targeting the catalytic subunit of protein phosphatase 2 for degradation.
It is a cytoplasmic protein found as a homodimer or heterodimer with Midline-2, and interacts with IGBP1 (Lymphocyte signaling protein A4).
Defects in MID1 are the cause of Opitz syndrome type I (OS-I), an X-linked recessive disorder characterized by hypertelorism, genital-urinary defects, cleft formations, imperforate anus, developmental delay, and congenital heart defects.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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