Thermo Fisher Scientific MID1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total TRI18.

Target Information

Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1.
Midline-1 belongs to the TRIM/RBCC family and contains:

• Two B box-type zinc fingers
• One B30.2/SPRY domain
• One COS domain
• One fibronectin type-III domain
• One RING-type zinc finger

Midline-1 is believed to have E3 ubiquitin ligase activity, targeting the catalytic subunit of protein phosphatase 2 for degradation.
It is a cytoplasmic protein found as a homodimer or heterodimer with Midline-2, and interacts with IGBP1 (Lymphocyte signaling protein A4).
Defects in MID1 are the cause of Opitz syndrome type I (OS-I), an X-linked recessive disorder characterized by hypertelorism, genital-urinary defects, cleft formations, imperforate anus, developmental delay, and congenital heart defects.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.