Thermo Fisher Scientific MMP14 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MMP14 for WB, IHC, and ELISA applications. Recognizes amino acids 185–299 of MMP14. Supplied as liquid, unconjugated form at 0.25 mg/mL. Ideal for research on extracellular matrix remodeling and tumor invasion.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:500 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| ELISA | 1:1,000 | - |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 185–299 in the N-terminal region of human matrix metalloproteinase-14 (membrane-type matrix metalloproteinase-1), conjugated to KLH. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_794898 |
Product Specific Information
Recommended positive control: A375.
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes including arthritis and metastasis.
Most MMPs are secreted as inactive proproteins activated by extracellular proteinases.
The protein encoded by this gene belongs to the membrane-type MMP (MT-MMP) subfamily, which contains a transmembrane domain suggesting expression at the cell surface.
This protein activates MMP2, and its activity may contribute to tumor invasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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