Thermo Fisher Scientific PCSK2 Polyclonal Antibody
Rabbit polyclonal antibody against PCSK2 for detection in human, rat, and monkey samples. Validated for Western blot. Recombinant full-length immunogen. Supplied in liquid form, unconjugated. For research use only.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant, full-length PCSK2 protein (amino acids 1–638) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Conditions | Store at 4 °C for short term. For long-term storage, keep at −20 °C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2158601 |
Product Specific Information
PA1-25306 detects NEC2 from human, rat, and monkey samples.
Target Information
The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins transported by the constitutive secretory pathway are also targeted for maturation by PCs.
PC family members share structural similarities, including:
- An approximately 10 kDa amino-terminal proregion
- A highly conserved ~55 kDa subtilisin-like catalytic domain
- A heterogeneous carboxyl-terminal domain
These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment.
Immunolocalization studies show that PC1 is found in the perinuclear region and trans-Golgi network, whereas PC2 is located in the trans-Golgi network and diffusely distributed in the peripheral cytoplasm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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