Thermo Fisher Scientific Phospho-BAD (Ser118) Polyclonal Antibody
Phospho-BAD (Ser118) 폴리클로날 항체로, 인산화된 BAD 단백질의 Ser118 잔기를 특이적으로 인식합니다. Western blot 및 IHC(P)에서 검증되었으며, Rabbit IgG 기반으로 제작되었습니다. 세포자멸사 조절 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S118 of human Bad |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.27 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979048 |
Target Information
The protein encoded by BAD is a member of the BCL-2 family, known regulators of programmed cell death. This protein promotes apoptosis by forming heterodimers with BCL-xL and BCL-2, counteracting their anti-apoptotic effects. The proapoptotic activity of BAD is regulated through phosphorylation. Protein kinases such as AKT and MAP kinase, as well as the phosphatase calcineurin, are involved in its regulation. Alternative splicing results in two transcript variants encoding the same isoform.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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