ELK Biotechnology ITGA2B (light chain form 1, Cleaved-Gln891) rabbit pAb
Integrin alpha-IIb 단백질을 인식하는 rabbit polyclonal antibody로, 혈소판 응집 관련 연구에 활용 가능. WB 및 IHC 분석에 적합하며, Human, Rat, Mouse 시료에서 반응. -20°C에서 1년간 안정적으로 보관 가능.
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제품명
ITGA2B (light chain form 1, Cleaved-Gln891) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Integrin alpha-IIb (GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2] |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human ITGA2B (light chain form 1, Cleaved-Gln891) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 16, 110 kD |
| Gene ID (Human) | 3674 |
| Human Swiss-Prot No. | P08514 |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. (provided by RefSeq, Jan 2016)
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