ELK Biotechnology FA11 (heavy chain, Cleaved-Arg387) rabbit pAb
인간 FA11 단백질의 Cleaved-Arg387 부위에서 유래한 합성 펩타이드로 제작된 토끼 폴리클로날 항체. WB 및 ELISA에 적합하며, 응고 인자 XI의 활성화 연구에 활용 가능. -20°C에서 1년 보관.
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제품명
FA11 (heavy chain, Cleaved-Arg387) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Coagulation factor XI (FXI; EC 3.4.21.27; Plasma thromboplastin antecedent; PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain] |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human FA11 (heavy chain, Cleaved-Arg387) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 40, 66 kDa |
| Gene ID (Human) | 2160 |
| Human Swiss-Prot No. | P03951 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Mouse |
Background
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
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