ELK Biotechnology FA9 (light chain, Cleaved-Arg191) rabbit pAb

제품명

FA9 (light chain, Cleaved-Arg191) rabbit pAb

제품 개요

이 항체는 인간 FA9 (light chain, Cleaved-Arg191)에서 유래한 합성 펩타이드를 면역원으로 제작된 폴리클로날 항체입니다. 비타민 K 의존성 응고인자 IX를 검출하며, 혈액 응고 과정 연구에 유용합니다.

제품 정보

Background

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca²⁺ ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions, and deletions, cause factor IX deficiency, a recessive X-linked disorder known as hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. (RefSeq, Sep 2015)