ELK Biotechnology Collagen XVIII α1 (Cleaved-His1572) rabbit pAb
Human 및 Mouse 시료에 반응하는 Collagen XVIII α1 (Cleaved-His1572) rabbit polyclonal antibody. WB와 ELISA에 적합하며, 고순도 IgG 형식으로 제공. Endostatin 관련 단백질 검출에 활용 가능. -20°C에서 1년간 안정적으로 보관.
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Collagen XVIII α1 (Cleaved-His1572) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Collagen XVIII α1 (Cleaved-His1572) rabbit pAb |
| Alternative Names | Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin] |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human Collagen XVIII α1 (Cleaved-His1572) |
| Species Reactivity | Human; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 20–200 kDa |
| GeneID (Human) | 80781 |
| Human Swiss-Prot No | P39060 |
| Storage | -20°C, 1 year |
| Host | Rabbit |
| Cellular Localization | Secreted, extracellular space, extracellular matrix, basement membrane; [Non-collagenous domain 1]: Secreted, extracellular space, extracellular matrix, basement membrane; [Endostatin]: Secreted, extracellular space, extracellular matrix, basement membrane |
Background
This gene encodes the alpha chain of type XVIII collagen, one of the multiplexins—extracellular matrix proteins containing multiple triple-helix domains interrupted by non-collagenous regions. The long isoform includes an N-terminal domain homologous to frizzled receptors. Proteolytic processing at several cleavage sites in the C-terminal region produces endostatin, a potent antiangiogenic protein that inhibits angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome, characterized by retinal abnormalities, suggesting type XVIII collagen’s role in retinal structure and neural tube closure. Alternative splicing generates multiple transcript variants. [RefSeq, Dec 2014]
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