ELK Biotechnology FA11 (light chain, Cleaved-Ile388) rabbit pAb

제품명

FA11 (light chain, Cleaved-Ile388) rabbit pAb

제품 개요

이 항체는 인간 응고인자 XI(FA11)의 경쇄(Cleaved-Ile388) 부위에서 유래한 합성 펩타이드를 면역원으로 제작된 토끼 폴리클로날 항체입니다. 혈액 응고 과정의 중간 단계에서 중요한 역할을 하는 Factor XIa를 검출하는 데 사용됩니다.

제품 정보

Background

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]