ELK Biotechnology FA11 (heavy chain, Cleaved-Glu19) rabbit pAb
FA11 (heavy chain, Cleaved-Glu19) rabbit pAb는 인간 FA11 유래 합성 펩타이드로 제작된 폴리클로날 항체입니다. WB와 ELISA에 사용 가능하며, 혈액 응고 관련 단백질 연구에 적합합니다. -20°C에서 1년 보관 가능하며, 사람 및 생쥐 반응성을 가집니다.
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제품 개요
FA11 (heavy chain, Cleaved-Glu19) rabbit pAb는 인간 FA11 단백질의 Cleaved-Glu19 부위에서 유래한 합성 펩타이드를 면역원으로 사용하여 제작된 폴리클로날 항체입니다. 혈액 응고 인자 XI 관련 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | FA11 (heavy chain, Cleaved-Glu19) rabbit pAb |
| Alternative Names | Coagulation factor XI (FXI; EC 3.4.21.27; Plasma thromboplastin antecedent; PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain] |
| Applications | WB; ELISA |
| Recommended Dilutions | WB: 1:1000–2000, ELISA: 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human FA11 (heavy chain, Cleaved-Glu19) |
| Storage | -20°C, 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 40, 66 kD |
| Gene ID (Human) | 2160 |
| Human Swiss-Prot No. | P03951 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Mouse |
Background
This gene encodes coagulation factor XI, a component of the blood coagulation cascade. It exists in plasma as a zymogen and is a unique plasma coagulation enzyme because it forms a homodimer of two identical polypeptide chains linked by disulfide bonds. Upon activation by factor XIIa (or XII), internal peptide bonds are cleaved, producing activated factor XIa — a serine protease composed of two heavy and two light chains held by disulfide bonds. Activated factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Defects in this factor cause Rosenthal syndrome, a blood coagulation abnormality. [Provided by RefSeq, Jul 2008]
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