ELK Biotechnology CATB (Cleaved-Asn126) rabbit pAb

제품명

CATB (Cleaved-Asn126) rabbit pAb

공급업체

ELK Biotechnology

제품 개요

Human CATB(Cathepsin B, Cleaved-Asn126) 유래 합성 펩타이드로 면역된 rabbit polyclonal antibody입니다. 단백질 분해 효소 관련 연구 및 tumor invasion, metastasis 연구에 활용됩니다.

스펙 정보

세포 내 위치

Lysosome, Melanosome, Secreted extracellular space, Apical cell membrane, Peripheral membrane protein, Extracellular side.
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity).

Background

• Catalytic activity: Hydrolysis of proteins with broad specificity for peptide bonds; preferential cleavage of -Arg-Arg-|–Xaa bonds in small molecule substrates.
• Function: Thiol protease involved in intracellular degradation and turnover of proteins; implicated in tumor invasion and metastasis.
• Similarity: Belongs to the peptidase C1 family.
• Subunit: Dimer of heavy and light chains cross-linked by a disulfide bond.