ELK Biotechnology CATB (Cleaved-Leu80) rabbit pAb

제품명

CATB (Cleaved-Leu80) rabbit pAb

공급업체

ELK Biotechnology

제품 개요

CATB(Cathepsin B)는 단백질 분해 효소로, 세포 내 단백질의 분해 및 재활용에 관여하며 종양 침습 및 전이에 관련된 것으로 알려져 있습니다. 본 항체는 인간 CATB의 Cleaved-Leu80 부위를 인식하는 rabbit polyclonal antibody입니다.

제품 스펙

세포 내 위치 (Cellular Localization)

Lysosome, Melanosome, Secreted extracellular space, Apical cell membrane, Peripheral membrane protein, Extracellular side.
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity).

기능 및 배경 (Background)

• Catalytic Activity: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|–Xaa bonds.
• Function: Thiol protease involved in intracellular protein degradation and turnover. Implicated in tumor invasion and metastasis.
• Similarity: Belongs to the peptidase C1 family.
• Subcellular Location: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
• Subunit: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.

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