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ELK Biotechnology BID (Cleaved-Arg71) rabbit pAb
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Cleaved-Arg71 부위를 인식하는 BID 단백질 특이 토끼 폴리클로날 항체로, WB 및 ELISA에 사용 가능. 인간 및 생쥐 반응성. 세포자멸사 관련 연구에 적합하며, -20°C에서 1년 보관 가능.
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- pk
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ELK Biotechnology ES19950-100UL BID (Cleaved-Arg71) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES19950-50UL BID (Cleaved-Arg71) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology BID (Cleaved-Arg71) rabbit pAb
ELK Biotechnology BID (Cleaved-Arg71) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | BID (Cleaved-Arg71) rabbit pAb |
| Alternative Names | BH3-interacting domain death agonist (p22 BID; BID) [Cleaved into: p15 BID, p13 BID, p11 BID] |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human BID (Cleaved-Arg71) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 8–22 kDa |
| Gene ID (Human) | 637 |
| Human Swiss-Prot No. | P55957 |
| Cellular Localization | Cytoplasm; Mitochondrion membrane; Mitochondrion outer membrane. When uncleaved, predominantly cytoplasmic. Cleaved forms (p15, p13) localize to mitochondrial membrane. |
| Species Reactivity | Human; Mouse |
Background
- Function: The intact BH3 motif is essential for pro-apoptotic activity and interaction with Bcl-2 family members. The major proteolytic product p15 BID facilitates cytochrome c release. Isoforms 1, 2, and 4 induce apoptosis, while isoform 3 does not.
- Post-translational Modifications (PTM): Phosphorylated upon DNA damage, likely by ATM or ATR. TNF-alpha induces caspase-mediated cleavage of p22 BID into p15, p13, and p11.
- Subcellular Location: Isoform 2 localizes to mitochondria; uncleaved BID is cytoplasmic; cleaved forms associate with the mitochondrial membrane.
- Subunit Interaction: Forms heterodimers with pro-apoptotic BAX or anti-apoptotic Bcl-2.
- Tissue Specificity: Isoforms 2 and 3 expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 in spleen, pancreas, placenta; isoform 3 in lung, pancreas, spleen; isoform 4 in lung and pancreas.
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