Thermo Fisher Scientific Phospho-TLR4 (Ser800) Polyclonal Antibody
TLR4의 Ser800 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 인간, 생쥐, 랫드 반응성. 고순도 액상 형태로 -20°C 보관.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TLR4 (Accession O00206), corresponding to amino acid residues around phosphorylated Ser800 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817141 |
Product Specific Information
This antibody detects endogenous levels of TLR4 only when phosphorylated at Ser800.
Target Information
TLR4 is a member of the Toll-like receptor (TLR) family, playing a fundamental role in pathogen recognition and activation of innate immunity. TLRs are conserved across species and share structural and functional similarities. TLR4 is most abundantly expressed in the placenta and in myelomonocytic leukocytes. It is a key component of the lipopolysaccharide (LPS) receptor complex, along with CD14 and LY96, mediating signal transduction induced by LPS from gram-negative bacteria. TLR4 recognizes pathogen-associated molecular patterns (PAMPs) and triggers cytokine production necessary for effective immune responses. Mutations in the TLR4 gene can affect LPS responsiveness. The receptor is expressed in monocytes, some B-cells, and placenta. TLR4-deficient mice show increased susceptibility to Gram-negative sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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