Thermo Fisher Scientific NRG1 Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPQLK EMKSQESAAG SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY STSTPFLSLP E

Target Information

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues.
It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs), and sensory and motor neuron-derived factor (SMDF).

They are tissue-specifically expressed and differ significantly in their structure:

• HRG isoforms contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains.
• GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains.
• SMDF isoform shares only the EGF-like domain with other isoforms.

The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.