Thermo Fisher Scientific RHOH Monoclonal Antibody (OTI8C7), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Target Information

The Rho subfamily of small GTP-binding proteins mediates many fundamental cellular functions. The commonly studied members (Rho, Rac, and CDC42) regulate actin reorganization and affect diverse cellular responses, including adhesion, cytokinesis, and motility.
RhoH, also known as TTF (Translocation Three Four), Rho-related GTP-binding protein and ras homolog gene family member H, is unlike most other small G proteins. Most small G proteins are expressed ubiquitously; however, RhoH is expressed only in hemopoietic cells and tissues.

Translocations and a high frequency of RhoH mutation have been detected in primary lymphoma cells. RhoH expression has also been observed in activated neutrophils. RhoH is GTPase deficient, remaining in a GTP-bound activated state without cycling. RhoH may be involved in the functional differentiation of T cells and in cytoskeleton organization.

The RhoH/TTF (ARHH) gene maps to chromosome 4p13 and encodes a 191-amino acid polypeptide.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.