Thermo Fisher Scientific mGluR8 (extracellular) Polyclonal Antibody
Rabbit polyclonal antibody targeting extracellular domain of mGluR8. Validated for WB and IHC (Frozen). High purity via antigen affinity chromatography. Supplied lyophilized, reconstitutable in DDW, stable at -20°C. For research use only.
- 카탈로그번호
- AGC-028-xxxxx (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific mGluR8 (extracellular) Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | (C)ENFG(S)KLGSHGKR, corresponding to amino acid residues 365–377 of rat mGluR8, extracellular N-terminus |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitution: Add 50 µL or 0.2 mL double-distilled water (DDW), depending on sample size.
Ships lyophilized at room temperature; store at -20°C upon arrival.
Reconstituted solution can be kept at 4°C for up to 1 week. For long-term storage, aliquot and keep at -20°C.
Avoid multiple freeze-thaw cycles.
Centrifuge antibody preparations before use (10,000 × g, 5 min).
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors.
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors divided into three groups based on sequence homology, signaling mechanisms, and pharmacologic properties:
- Group I: GRM1, GRM5 – activate phospholipase C
- Group II: GRM2, GRM3 – inhibit cyclic AMP cascade
- Group III: GRM4, GRM6, GRM7, GRM8 – inhibit cyclic AMP cascade with distinct agonist selectivities
Glutamatergic neurotransmission is essential for normal brain function and implicated in neuropathologic conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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