Thermo Fisher Scientific mGluR8 (extracellular) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitution: Add 50 µL or 0.2 mL double-distilled water (DDW), depending on sample size.
Ships lyophilized at room temperature; store at -20°C upon arrival.
Reconstituted solution can be kept at 4°C for up to 1 week. For long-term storage, aliquot and keep at -20°C.
Avoid multiple freeze-thaw cycles.
Centrifuge antibody preparations before use (10,000 × g, 5 min).

Target Information

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors.
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors divided into three groups based on sequence homology, signaling mechanisms, and pharmacologic properties:

• Group I: GRM1, GRM5 – activate phospholipase C
• Group II: GRM2, GRM3 – inhibit cyclic AMP cascade
• Group III: GRM4, GRM6, GRM7, GRM8 – inhibit cyclic AMP cascade with distinct agonist selectivities

Glutamatergic neurotransmission is essential for normal brain function and implicated in neuropathologic conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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