Thermo Fisher Scientific ATP6V1A Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total ATP6V1A.

Target Information

ATP6V1A encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles.
V-ATPase-dependent organelle acidification is necessary for intracellular processes such as:

• Protein sorting
• Zymogen activation
• Receptor-mediated endocytosis
• Synaptic vesicle proton gradient generation

V-ATPase is composed of:

• V1 domain (cytosolic): three A and three B subunits, two G subunits, plus C, D, E, F, and H subunits; contains ATP catalytic site
• V0 domain (transmembrane): five different subunits (a, c, c’, c”, and d)

Additional isoforms of many subunit proteins are encoded by multiple genes or alternatively spliced transcript variants.
This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues.
Transcript variants derived from alternative polyadenylation exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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