Thermo Fisher Scientific Human TLR3 Synthetic Peptide
인간 TLR3 단백질의 C-말단 15개 아미노산 서열에 해당하는 합성 펩타이드입니다. TLR3 항체(PA5-20183)와 함께 차단 실험용으로 사용됩니다. 200 µg/mL 농도의 액상 형태로 제공되며, PBS(pH 7.2)와 0.1% BSA, 0.02% sodium azide를 포함합니다. -20°C에서 보관하며, 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Human TLR3 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human TLR3.
PEP-0298 can be used as a blocking peptide with polyclonal antibody PA5-20183.
Target Information
TLR3 (Toll-like receptor 3, CD283) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity.
TLRs are highly conserved from drosophila to humans and share structural and functional similarities.
TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for effective immunity.
TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of leukocytes.
It recognizes dsRNA associated with viral infection, inducing activation of NF-kappaB and production of type I interferons.
TLR3 may play a role in host defense against viruses, including Influenza A and West Nile Virus, and mediates viral entry mechanisms.
TLR3 signaling differs from other human TLRs in that it utilizes TRIF instead of MyD88, leading to activation of IRF-3 and NF-kB pathways and induction of inflammatory cytokines that promote dendritic cell maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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